You will rarely be in a situation where an entire item pool has been exhausted, though, so don’t try to incorporate this into your strategy when you find a box. That said, if the item pool Pandora’s Box tries to use has already been exhausted, it will instead spawn an item from the Treasure Room item pool. Boss reward pool, Devil deal pool or Angel deal pool.

With one exception, Pandora’s Box calls items from a set item pool when used on floors that would make it spawn a pedestal item, e.g.

Keep in mind that if you do not have Repentance active/installed, using the ? Card will just consume the box as if you had used it normally.

With the Repentance DLC loaded, the consumable – will not consume single use active items such as Pandora’s Box, meaning you can consume the card to gain a reward for the current floor without consuming Pandora’s Box.

The Afterbirth passive item – does not double the reward gained from using Pandora’s Box, no matter what floor you’re on.

When on an XL Floor because of Curse of the Labyrinth, refer to the first floor of your current chapter.

Keep in mind your active item slot will be occupied by the box until you leave it behind or use it, so unless you have the – passive item or use the –, you won’t be able to keep any other active items when doing this method. This means you can carry the box with you to future floors if you wish to take advantage of a certain floor’s effects, all of which are listed in the section below.

It will spawn a different combination of pickups or pedestal items depending on what your current floor and chapter are (you can hold tab to see what the current stage is called Basement I, Utero II, Cathedral, etc.).

Its one-time use nature means it will disappear after the first use, so decide carefully when to open it up! It is unlocked by beating Dark Room as Lazarus for the first time, and once unlocked, it will show up in the Red Chest and Shop item pools on future runs as well in as the Greed/Greedier mode shops.

– is a one-time use item that takes up the Active slot.

The basics of Pandora’s Box (if you’re already familiar with the item, you can skip this)

Unlocks Moving Box in Afterbirth+, otherwise nothing Basement, Cellar, Burning Basement, Downpour, DrossĬaves, Catacombs, Flooded Caves, Mines, Ashpitĭepths, Necropolis, Dank Depths, Mausoleum, Gehenna

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